Alteraciones histológicas causadas por la administración intraperitoneal de ebulina en ratones

La ebulina es una proteína inhibidora de ribosomas tipo 2 con actividad lectina (RIL) aislada del saúco enano. Los frutos del saúco se han consumido desde la antigüedad por sus atribuidos efectos medicinales. En la actualidad se está estudiando su posible uso en la terapia contra el SIDA y como antineoplásico. Nos planteamos, por tanto, un estudio experimental para valorar la toxicidad de esta proteína antirribosómica.Grado en Medicin

The European heritage of folk medicines and medicinal foods: Its contribution to the CAMs of tomorrow

[No abstract available

Effect of Temperature and Successive Sprays on Liquid Distribution in Fluidized Beds

Liquid injection in gas-solid fluidized beds is used in several industrial processes including food additive production, manufacturing of fertilizers, intermediate processing of pharmaceutical capsules and oil refining (i.e., Fluid CokingTM and Fluid Catalytic Cracking (FCC)). Good quality in the liquid distribution on the fluidized particles is fundamental in these processes either to ensure uniformity in the formation of desirable agglomerates, or to minimize their formation when undesirable. In the Fluid Coking process, for example, improving the liquid distribution and minimizing agglomerate formation will result in increasing the overall yield of the process and avoid operability problems. A new experimental model that simulates agglomerate formation in fluidized beds and investigates their stability was developed and tested at pilot plant scale. The model can be adapted to model different processes, but, in this work, Fluid CokingTM was selected as an example of a system to model. The liquid content of the agglomerates was estimated with a new, simple and accurate procedure that can be applied to the whole mass of the recovered agglomerates. This procedure was extended to estimate the recoating of individual agglomerates by different sprays resulting from multiple feed jets. The results indicated that reducing the average bed temperature or the mass of injected liquid (liquid load) enhanced the liquid distribution. Also, the maximum extent of liquid spread from wet to dry particles was estimated. The results indicated that the spreading is not a significant factor in reactors such as Fluid Cokers

Efectos del ciclo menstrual en el estado físico y psicológico de una mujer activa

The main objectives of this research were to analyze the effects of the different phases of the menstrual cycle (MC) on two elements of the physical condition, strength-power and dynamic balance, and on the psychological state of a moderately active woman. A 28-year-old woman participated in this study, who used oral contraceptives. In total, 6 sessions were recorded, corresponding to 2 complete menstrual cycles and each of its phases (menstrual, follicular and luteal). In each session, three tests were carried out to evaluate the physical condition variables (Leg extension in Kineo, Press Bench in Multipower and Y Balance Test) and a test for psychological variables (POMS Test). The results obtained showed that during the luteal phase the participant achieved the lowest values ​​in the 3 physical tests of power and dynamic balance, being the follicular phase (FP) where she obtained the best performance. In the psychological test, the menstrual phase (MP) stands out for having the highest values ​​in the fatigue-inertia dimension, in contrast to the FP where higher values ​​were observed for the vigor-activation dimensión. The personal questionnaire on MC revealed the presence of menstrual and premenstrual symptoms in the two cycles studied. It is suggested that the changes produced in the physical and psychological variables of the subject are due to the presence of premenstrual symptoms, without being able to confirm the hormonal influence as blood or urine tests have not been performed.Los principales objetivos de esta investigación fueron analizar los efectos de las diferentes fases del ciclo menstrual (CM) sobre dos elementos de la condición física, la fuerza- potencia y el equilibrio dinámico, y sobre el estado psicológico de una mujer moderadamente activa. En este estudio participó una mujer de 28 años, la cual consumía anticonceptivos orales. En total se registraron 6 sesiones que correspondieron a 2 ciclos menstruales completos y a cada una de sus fases (menstrual, folicular y lútea). En cada sesión se realizaron tres pruebas para evaluar las variables de la condición física (Leg extensión en Kineo, Press Banca en Multipower e Y Balance Test) y un test para las variables psicológicas (Test de POMS). Los resultados obtenidos mostraron que durante la fase lútea (FL) la participante consiguió los valores más bajos en las 3 pruebas físicas de potencia y equilibrio dinámico, siendo la fase folicular (FF) donde mejor desempeño obtuvo. En la prueba psicológica, se destaca la fase menstrual (FM) por tener los valores más altos en la dimensión de fatiga-inercia, en contraposición con la FF donde se observaron valores más altos para la dimensión de vigor-activación. El cuestionario personal sobre el CM reveló la presencia de síntomas menstruales y premenstruales en los dos ciclos estudiados. Se sugiere que los cambios producidos en las variables físicas y psicológicas de la sujeto, se deban a la presencia de síntomas premenstruales, sin poder confirmar la influencia hormonal al no haberse realizado análisis de sangre u orina

Efectos del ejercicio físico en la dismenorrea primaria. Revisión sistemática

Primary dysmenorrhea (PD) is the most common menstrual disorder and is defined as painful menstruation. This health problem reduces the quality of life of more than 70% of women who suffer from it, so the main objectives of this review were to assess whether physical exercise was safe for these women and, knowing its effects on PD, compare the different exercises or training methods by analyzing which are the most effective. In this paper, articles from the PubMed database were reviewed, selecting those written in Spanish and English that were no more than 5 years old and choosing intervention studies to perform the analysis. In addition, the information was completed with the website of The American College of Obstetricians and Gynecologists. Interventions pointed to physical exercise as a positive treatment for PD. The most significant improvements were obtained in the pain and intensity of menstruation. There were also reductions in menstrual distress, duration of pain and painkillers consumed, as well as improvements in quality of life. It is concluded that regular physical exercise is a safe and effective method to reduce the symptoms caused by PD. Long-term exercise will also have beneficial effects in the long run, further reducing these symptoms and improving the overall health of the person. In addition, it should be noted that this treatment does not generate side effects in the body. Aerobic exercise seems to be the most effective training method for dysmenorrhea symptoms, followed by some stretching exercises or yoga.La dismenorrea primaria (DP) es el trastorno menstrual más común y se define como menstruación dolorosa. Este problema de salud reduce la calidad de vida de más del 70% de las mujeres que lo padecen, por lo que los principales objetivos de esta revisión fueron evaluar si realizar ejercicio físico era seguro para estas mujeres y, conociendo sus efectos en la DP, comparar los distintos ejercicios o métodos de entrenamiento analizando cuáles son los más eficaces. En este trabajo se revisaron artículos procedentes de la base de datos PubMed, seleccionando aquellos escritos en castellano e inglés, que no tuviesen más de 5 años y escogiendo estudios de intervención para realizar el análisis. Además, se completó la información con la página web del Colegio Americano de Obstetras y Ginecólogos. Las intervenciones señalaron al ejercicio físico como un tratamiento positivo para la DP. Las mejoras más significativas se obtuvieron en el dolor e intensidad de la menstruación. También hubo reducciones en la angustia menstrual, la duración del dolor y en los analgésicos consumidos, así como mejoras en la calidad de vida. Se concluye que el ejercicio físico realizado de una forma regular es un método seguro y eficaz para reducir los síntomas producidos por la DP. La práctica prolongada en el tiempo también tendrá efectos beneficiosos a la larga, reduciendo aún más estos síntomas y mejorando la salud en general de la persona. Además, cabe destacar que este tratamiento no genera efectos secundarios en el organismo. El ejercicio aeróbico parece ser el método de entrenamiento más efectivo para los síntomas dismenorreicos, seguido de algunos ejercicios de estiramiento o el yoga

Cold H2O and CO ice and gas toward the Galactic Center

We present observations of CO, 13CO and of H2O in the middle and far-infrared taken with the ISO-SWS and ISO-LWS spectrometers toward two positions in the Galactic Center region (Sgr A* and GCS-3). Both ice and gas phase molecules are detected. The ISO data have been complemented with observations of the J=3-2 and J=7-6 lines of CO carried out at the Caltech Submillimeter Observatory. The ISO and CSO data indicate that the absorbing gas is extremely cold, T_K ~ 10 K, suggesting that it is located in the dark clouds of the different spiral arms that intersect the line of sight towards the Galactic Center. From the analysis of the CO absorption we derive 13CO gas phase column densities of 1.1 and 0.7E17 cm-2 towards Sgr A* and GCS-3, respectively. The H2O gas column density in the direction of Sgr A* is ~ 2E16 cm-2. The derived CO/H2O and gas/solid abundance ratios corresponding to these cold clouds are remarkably similar along the two lines of sight. We find that nearly all the CO is in the gas phase, while the H2O is almost entirely frozen onto the surfaces of cold dust grains. Finally, the N_{gas+ice}(CO)/N_{gas+ice}(H2O) abundance ratio is ~5 implying that H2O formation processes are highly efficient.Comment: Accepted by ApJ Letter

REACHING FOR BLUE GOLD - How the EU can rise to the water challenge while reaping the rewards. EPC Issue Paper No. 80, November 2015

Foreword. Climate change is bad news for water resources – and thus for human development, societies, economies, the environment, and local and global security. The increasing frequency and severity of extreme weather events such as droughts and floods serves as a reminder of the effects climate change can have on the quantity and quality of global water reserves, and thus on various other aspects of life. Even though the effects differ from region to region, this is a global challenge with far-reaching consequences to which Europe is not immune. As the world leaders gather in Paris in December 2015 to discuss a new international climate deal, it is worth to remind politicians, businesses and citizens of the water challenge and its wider implications, which already affect us today – and which will only get worse with climate change. However, water-related risks resulting from climate change are not a fatality and damage control doesn’t have to be the only mantra. Placing the water challenge at the centre of political and security dialogues, development strategies and climate mitigation and adaptation measures, and implementing smarter water management, could also bring great economic, environmental and social benefits, in and outside the European Union. It would also contribute to global security. Water matters – now more than ever. This is also what this publication demonstrates. Building on the European Policy Centre’s, two-year “Blue Gold” project, this publication shows the rationale for action, how the EU could use its existing internal and external policy instruments to tackle the water challenge with its various dimensions and the benefits of action

Diseño geotécnico de jarillones

Actualmente Colombia requiere de criterios para el diseño geotécnico de jarillones, estructuras que son usadas para la contención de agua y prevención de inundaciones. La forma en que se presentan las inundaciones y las características de las mismas no son iguales en todas las zonas del país. Debido a esto se requiere generar una serie de criterios para estos diseños con base en experiencias vividas en los últimos años del país. Es por eso que a través de herramientas de modelación tales como Hydrus 2.0 y SLIDE 5.0 se desarrollaron ciertos escenarios en los cuales se simularon diversos tipos de jarillones con el fin de obtener criterios geotécnicos para el diseño de jarillones.Colombia presently requires geotechnical design criteria for levees, structures that are used for water containment and flood prevention. The ways in which floods and their characteristics are presented are not equal in all areas. Because it is necessary to generate a set of criteria for these designs based on experiences in recent years in the country. That's why through modeling tools such as Hydrus 2.0 and SLIDE 5.0 certain scenarios in which different types of dikes in order to obtain geotechnical design criteria for levees were simulated were developed.Ingeniero (a) CivilPregrad

Viabilidad y ventajas de la implementación de gobierno corporativo en empresas de familia Colombia

108 páginas : ilustraciones, gráficos.The implementation of a Corporate Government in the companies affects in a constant improvement in the management inside the organizations, unleashing with it a well-being to all the levels of the company since it it can be a major access to sources of financing, increase in the valuation of the company, better operational performance, minor operative and financial risks, as well as better relations with other related parts. In the national context the topic of implementation of Corporate Government has had major relevancy in the financial institutions or companies that quote in bag. Nevertheless, there has not been born in mind that the Colombian economy supports in the family enterprises, which were representing a year 2014, 70 % of the Colombian industry and were contributing between 45 % and 70 % of the Internal Brute Product, (GDP) this based on a study realized by the Superintendence of Companies, affecting in a significant way so much the economic as social development of the country (National Institute of Public Book-keepers, 2014). For this reason the present dissertation has for aim determine the viability of implementing a Corporate Government in the of Columbus companies of family in the light of the Colombian Guide of Corporate Government for Closed Companies and of Family.La implementación de un Gobierno Corporativo en las empresas incide en una mejora continua en la gestión dentro de las organizaciones, desencadenando consigo un bienestar a todos los niveles de la empresa como lo puede ser un mayor acceso a fuentes de financiamiento, incremento en la valoración de la empresa, mejor desempeño operacional, menores riesgos operativos y financieros, así como mejores relaciones con otras partes relacionadas. En el contexto nacional el tema de implementación de Gobierno Corporativo ha tenido mayor relevancia en las instituciones financieras o compañías que cotizan en bolsa. Sin embargo, no se ha tenido en cuenta que la economía colombiana se soporta en las empresas familiares, las cuales representaban al año 2014, el 70% de la industria colombiana y aportaban entre 45% y 70% del Producto Interno Bruto, (PIB) esto basado en un estudio realizado por la Superintendencia de Sociedades, afectando de manera significativa tanto el desarrollo económico como social del país (Instituto Nacional de Contadores Públicos, 2014).Por esta razón la presente disertación tiene por objetivo determinar la viabilidad de implementar un Gobierno Corporativo en las empresas de familia colombinas a la luz de la Guía Colombiana de Gobierno Corporativo para Sociedades Cerradas y de FamiliaContador PúblicoPregrad